Upregulation of the expression of vasopressin gene in the paraventricular and supraoptic nuclei of the lithium-induced diabetes insipidus rat
1997; Elsevier BV; Volume: 772; Issue: 1-2 Linguagem: Inglês
10.1016/s0006-8993(97)00887-1
ISSN1872-6240
AutoresHirofumi Anai, Yoichi Ueta, Ryota Serino, Masayoshi Nomura, Narutoshi Kabashima, Izumi Shibuya, Masayuki Takasugi, Yasuhide Nakashima, Hiroshi Yamashita,
Tópico(s)Ion Transport and Channel Regulation
ResumoThe expression of arginine vasopressin (AVP) gene in the paraventricular (PVN) and supraoptic nuclei (SON) was investigated in rats with lithium (Li)-induced polyuria, using in situ hybridization histochemistry and radioimmunoassay. The male Wistar rats consuming a diet that contained LiCl (60 mmol/kg) for 4 weeks developed marked polyuria. The Li-treated rats produced a large volume of hypotonic urine with low ionic concentrations. Plasma sodium concentrations were found to be slightly increased in the Li-treated rats compared with those in controls. Plasma concentration of AVP and transcripts of AVP gene in the PVN and SON were significantly increased in the Li-treated rats compared with controls. These results suggest that dehydration and/or the activation of visceral afferent inputs may contribute to the elevation of plasma AVP and the upregulation of AVP gene expression in the PVN and the SON of the Li-induced diabetes insipidus rat.
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