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Separate Renal Function Studies in Predominantly Unilateral Hydronephrosis

1958; Wiley; Volume: 47; Issue: 5 Linguagem: Inglês

10.1111/j.1651-2227.1958.tb07670.x

1651-2227

Rolf Zetterström, N. O. Ericsson, Jan Winberg,

Electrolyte and hormonal disorders

Acta PaediatricaVolume 47, Issue 5 p. 540-548 Separate Renal Function Studies in Predominantly Unilateral Hydronephrosis1 ROLF ZETTERSTRÖM, ROLF ZETTERSTRÖM Pediatric Clinic, Karolinska Sjukhuset, StockholmSearch for more papers by this authorNILS OLOF ERICSSON, NILS OLOF ERICSSON Pediatric Clinic, Karolinska Sjukhuset, StockholmSearch for more papers by this authorJAN WINBERG, JAN WINBERG Pediatric Clinic, Karolinska Sjukhuset, StockholmSearch for more papers by this author ROLF ZETTERSTRÖM, ROLF ZETTERSTRÖM Pediatric Clinic, Karolinska Sjukhuset, StockholmSearch for more papers by this authorNILS OLOF ERICSSON, NILS OLOF ERICSSON Pediatric Clinic, Karolinska Sjukhuset, StockholmSearch for more papers by this authorJAN WINBERG, JAN WINBERG Pediatric Clinic, Karolinska Sjukhuset, StockholmSearch for more papers by this author First published: September 1958 https://doi.org/10.1111/j.1651-2227.1958.tb07670.xCitations: 17 1 Aided by a grant from Stockholms Stads Foundation for Medical Research. AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat Summary Preliminary investigation of acidification and concentration power of each kidney in two patients with predominantly unilateral hydronephrosis due to congenital ureteropelvic obstruction, the following conclusions may be drawn. In the hydronephrotic kidney there was an impairment of the water reabsorption and a defective acid-base regulation. As maximal reabsorption of bicarbonate took place in the hydronephrotic kidney during an acid load, the proximal parts of the tubules cannot have been severely damaged. Signs of distal tubular damage were suggested by a limited capability of the kidney to lower the pH of the urine, and to produce a concentrated urine. Etudes seaparées des fonctionnements rénaux dans ľ hydronéphrose pour la plupart unilatérale. En se basant sur ľ'investigation préliminaire du pouvoir ? acidification et de concentration de chaque rein chez 2 malades avec une hydronéphrose principalement unilatérale, due à une obstruction ultéro-pelvienne congénitale, on peut tirer les conclusions suivantes: Dans le rein hydronéphrotique, il y avait une diminution dans la réadsorption ? eau et une régulation defectueuse de la base d'acide. Etant donné qu'une réadsorption maxima de bicarbonate s'observe dans le rein néphrotique pendant une charge ?acide, les parties voisines des tubules ne peuvent pas être sérieusement lésées. Une possibilityé réduite du rein pour abaisser le pH de ľurine et pour produire une urine concentrée font penser à une détérioration du tubule distal. Ge sonderte Nierenfunktlons-Studien bei vorwiegend unilateraler Hydronephrosis. Auf Grund einer vorläufigen Untersuchung betreffend Säuerung und Koncentrationsvermögen der beiden Nieren zweier Patienten mit vorwiegend unilateraler Hydronephrosis, verursacht durch congenitalen Ureter -Nierenbecken-Verschluss, können folgende Sehlussfolgerungen gezogen werden: In der hydronephrotischen Niere bestand eine verschlechterte Wasserrückresorp-tion und eine defekte Saure-Basen-Regulation. Eine maximale Rückresorption von Bikarbonat fand während einer Säurebelastung in der hydronephrotischen Niere statt, die proximalen Teile der Tubuli können also nicht ernstlich beschädigt worden sein. Ein Schaden an den distalen, tubulären Teilen wird vermutet, da die Niere nur eine begrenzte Fähigkeit zur Herabsetzung des pH des Urins sowie zur Produktion eines konzentrierten Urins aufwies. Estudios de la función renal por separado en hidronefrosis predominantemente unilaterales. Del estudio preliminar de la capacidad de acidificación y concentración de cada riñón, en dos pacientes con hidronefrosis predominantemente unilateral por obstructión congénita ureteropélvica, se desprenden las siguientes conclusiones. En el riñón hidronefrótico existía tin transtomo de la reabsorción hídrica y una regulateón acido-base deficitaria. Las porciones proximales de los tubulos no podían estar gravemente lesionados ya que tuvo lugar una reabsorción de bicarbonato máxima, en el riñón hidronefrótico, durante la sobrecarga ácida. La limitatión de la capacidad del riñón para descender el pH de la orina, y segregar una orina concentrada sugerían la existencia de lesiones tubulares distales. References Bowman, R. L., Trantham, H. V. AND Caulfield, P. A.: An instrument and method for rapid, dependable determination of freezing-point depression. J. Lab. & Clin. Med., 43: 310, 1954. CASPubMedWeb of Science®Google Scholar Ericsson, N. O., Winberg, J. AND Zetterström, R.: Renal function in infantile obstructive uropathy. Acta pcediat., 44: 444, 1955. 10.1111/j.1651-2227.1955.tb04267.x CASPubMedGoogle Scholar Pitts, R. F.: Modern concepts of acid-base regulation. Arch. Int. Med., 89: 864, 1952. 10.1001/archinte.1952.00240060007002 CASPubMedWeb of Science®Google Scholar Platt, R.: Structural and functional adaptation in renal failure. Brit. M. J., 1: 1313, 1952. 10.1136/bmj.1.4772.1313 CASPubMedWeb of Science®Google Scholar Rapofort, S., Brodsky, W. A., West, C. D. AND Mackler, B.: Urinary flow and excretion of solutes during osmotic diuresis in hydropenic man. Am. J. Physiol., 156: 433, 1949. PubMedWeb of Science®Google Scholar Roussak, N. J. AND Oleesky, S.: Water-losing nephritis. A syndrome simulating diabetes insipidus. Quart. J. Med., 23: 147, 1953. Web of Science®Google Scholar Smith, H. W.: The Kidney. Oxford University Press, New York , 1951, pp. 244, 257. Web of Science®Google Scholar Van Slyke, D. D. AND Neill, J. M.: The determination of gases in blood and other solutions by vacuum extraction and manometric measurement. J. Biol. Chem., 61: 523, 1924. Google Scholar Citing Literature Volume47, Issue5September 1958Pages 540-548 ReferencesRelatedInformation