Artigo Revisado por pares

Antithrombogenicity of fluorinated diamond-like carbon films

2004; Elsevier BV; Volume: 14; Issue: 3-7 Linguagem: Inglês

10.1016/j.diamond.2004.09.017

ISSN

1879-0062

Autores

Toshiya Saito, Terumitsu Hasebe, Satoshi Yohena, Yoshiaki Matsuoka, Aki Kamijo, Koki Takahashi, Tetsuya Suzuki,

Tópico(s)

Lubricants and Their Additives

Resumo

Effects of doping with fluorine to diamond-like carbon (DLC) films on the antithrombogenicity were investigated by changing its content. Fluorinated DLC (F-DLC) films were prepared on silicon (Si) substrates using radio frequency (RF) plasma enhanced chemical vapour deposition (CVD) by changing the ratio of hexafluoroethane (C2F6) and acetylene (C2H2). The contact angle measurements of human whole blood droplet on Si, DLC and F-DLC were 24.2°, 60.8° and 95.3°, respectively. Furthermore, the static evaluation of F-DLC films incubated with platelet-rich plasma (PRP) showed dramatic reduction of platelet adhesion and activation on the surface. It was found that the addition of fluorine into DLC films much improved antithrombogenicity, which was clearly shown by scanning electron microscopy (SEM) with statistical analysis. F-DLC coating can be a great candidate for developing antithrombogenic surfaces in blood contacting materials.

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