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Chronic red blood cell exchange to prevent clinical complications in sickle cell disease

2005; Elsevier BV; Volume: 32; Issue: 3 Linguagem: Inglês

10.1016/j.transci.2005.03.003

1878-1683

S Cabibbo, Carmelo Fidone, Giovanni Garozzo, Agostino Antolino, Giovanna Oriella Manenti, Francesco Bennardello, Vincenzo Licitra, Salvatore Calabrese, Francesco Costantino, Simone Travali, Roberto Distefano, Pietro Bonomo,

Erythrocyte Function and Pathophysiology

We tracked the results of 394 manual or automatic red blood cell exchanges done with a cell separator in 20 sickle cell patients at high risk for recurrent complications. Over an average of 6 years, none of the patients developed complications related to the procedure or to the increased blood use. It was safe and effective in preventing complications of sickle cell disease, and if done automatically, reduced iron overload. Ferritin levels also decreased in patients treated with automatic red blood cell exchange. Furthermore, using Single Donor Red Blood Cell units (SDRC) we reduced the potential exposure to transfusion transmitted infectious diseases (TTI).