Suppression of gastric ulcer induced by stress and HCL-ethanol by intravenously administered metallothionein-II
1988; Elsevier BV; Volume: 151; Issue: 2 Linguagem: Inglês
10.1016/s0006-291x(88)80340-1
ISSN1090-2104
AutoresTSUTOMU MIMURA, Kazutake Tsujikawa, Naohiro Yasuda, Hiroshi Nakajima, Munetada Haruyama, Takao Ohmura, Masaru Okabe,
Tópico(s)Plant Micronutrient Interactions and Effects
ResumoA metallothionein isoform metallothionein-II was isolated from the livers of zinc acetate-treated rats. Metallothionein-II, which showed a single band on polyacrylamide gel electrophoresis, was subjected to two kinds of anti-ulcer screening systems. It was shown that intravenously administered metallothionein-II suppressed the formation of rat water-immersion stress- and HCI-ethanol-induced gastric ulcer significantly. The effect may partly be derived from the zinc contained in the metallothionein-II. However, the effect of metallothionein-II was much stronger than that of an equivalent mole of zinc. Apparently, metallothionein-II had an anti-ulcerogenic activity not based on the effect of intrinsic zinc.
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