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Amide proton transfer imaging of human brain tumors at 3T

2006; Wiley; Volume: 56; Issue: 3 Linguagem: Inglês

10.1002/mrm.20989

1522-2594

Craig Jones, Michael Schlosser, Peter C.M. van Zijl, Martin G. Pomper, Xavier Golay, Jinyuan Zhou,

Advanced NMR Techniques and Applications

Abstract Amide proton transfer (APT) imaging is a technique in which the nuclear magnetization of water‐exchangeable amide protons of endogenous mobile proteins and peptides in tissue is saturated, resulting in a signal intensity decrease of the free water. In this work, the first human APT data were acquired from 10 patients with brain tumors on a 3T whole‐body clinical scanner and compared with T 1 ‐ ( T 1 w) and T 2 ‐weighted ( T 2 w), fluid‐attenuated inversion recovery (FLAIR), and diffusion images (fractional anisotropy (FA) and apparent diffusion coefficient (ADC)). The APT‐weighted images provided good contrast between tumor and edema. The effect of APT was enhanced by an approximate 4% change in the water signal intensity in tumor regions compared to edema and normal‐appearing white matter (NAWM). These preliminary data from patients with brain tumors show that the APT is a unique contrast that can provide complementary information to standard clinical MRI measures. Magn Reson Med, 2006. © 2006 Wiley‐Liss, Inc.