Serum BMP-4 Levels in Relation to Arterial Stiffness and Carotid Atherosclerosis in Patients with Type 2 Diabetes
2011; Future Medicine; Volume: 5; Issue: 6 Linguagem: Inglês
10.2217/bmm.11.81
ISSN1752-0371
AutoresJang Won Son, Eun-Hee Jang, Meekyoung Kim, Ki‐Hyun Baek, Ki‐Ho Song, Kun‐Ho Yoon, Bong‐Yun Cha, Ho‐Young Son, Kwang‐Woo Lee, Hanjoong Jo, Hyuk‐Sang Kwon,
Tópico(s)Biomarkers in Disease Mechanisms
ResumoAim: The aim of this study was to evaluate the association between the circulating BMP-4 levels and atherosclerosis in patients with Type 2 diabetes. Material & methods: Serum BMP-4 levels were measured in 174 diabetic patients, and the degree of atherosclerosis was assessed by measuring the carotid intima-media thickness and the cardio-ankle vascular index. Results: Serum BMP-4 levels were inversely correlated with systolic blood pressure, triglycerides, free fatty acids, cardio-ankle vascular index and carotid intima-media thickness. Lower BMP-4 levels were shown to be an independent predictor of the increased cardio-ankle vascular index and carotid intima-media thickness after adjusting for conventional cardiovascular risk factors in patients with Type 2 diabetes. Conclusion: Serum BMP-4 levels are inversely associated with surrogate markers of arterial stiffness and carotid atherosclerosis in patients with Type 2 diabetes.
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