Changes in pituitary hormone levels induced by met-enkephalin in man—The role of dopamine
1981; Elsevier BV; Volume: 29; Issue: 15 Linguagem: Inglês
10.1016/0024-3205(81)90254-x
ISSN1879-0631
AutoresGiuseppe Delitala, Ashley Grossman, G. M. Besser,
Tópico(s)Stress Responses and Cortisol
ResumoThe interaction of dopamine with the effects of the opiate agonist peptide D-Ala2-MePhe4-met-enkephalin-O-o1 (DAMME) on anterior pituitary hormone secretion was investigated in normal male subjects. DAMME produced clear elevations in prolactin, growth hormone and thyroid-stimulating hormone, while inhibiting the release of luteinising hormone and cortisol. There was no change in follicle stimulating hormone. The elevations in prolactin and TSH were enhanced by the dopamine antagonist, domperidone, and blocked by an infusion of dopamine. Neither dopamine nor domperidone modulated the changes in growth hormone, luteinising hormone or cortisol. The data are comptible with the association of the release of prolactin and TSH by opiate peptides with decreased hypothalamic dopaminergic activity; changes in the other anterior pituitary hormones seem to involve different mechanisms.
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