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Cyathane diterpenes from Sarcodon cyrneus and evaluation of their activities of neuritegenesis and nerve growth factor production

2007; Elsevier BV; Volume: 15; Issue: 8 Linguagem: Inglês

10.1016/j.bmc.2007.02.019

1464-3391

Maria Carla Marcotullio, Rita Pagiotti, Federica Maltese, Gildas Norbert Oball‐Mond Mwankie, Tomohiro Hoshino, Yutaro Obara, Norimichi Nakahata,

Chemical synthesis and alkaloids

Two new cyathane diterpenes, cyrneine C (4) and D (5), were isolated from the mushroom Sarcodon cyrneus, along with previously isolated cyrneine A, B and glaucopine C. The structures of the novel diterpenoids were determined by the analysis of spectroscopic data. Effects of the cyrneines and glaucopine C on the NGF gene expression in 1321N1 cells and on neurite outgrowth on PC12 cells were evaluated.