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Nomogram Predictive of Pathological Inguinal Lymph Node Involvement in Patients With Squamous Cell Carcinoma of the Penis

2006; Lippincott Williams & Wilkins; Volume: 175; Issue: 5 Linguagem: Inglês

10.1016/s0022-5347(05)01003-7

1527-3792

Vincenzo Ficarra, Filiberto Zattoni, Walter Artibani, A. Fandella, Guido Martignoni, Giacomo Novara, T. Prayer Galetti, T Zambolin, Michael W. Kattan,

Urologic and reproductive health conditions

No AccessJournal of UrologyAdult urology1 May 2006Nomogram Predictive of Pathological Inguinal Lymph Node Involvement in Patients With Squamous Cell Carcinoma of the Penis Vincenzo Ficarra, Filiberto Zattoni, Walter Artibani, Andrea Fandella, Guido Martignoni, Giacomo Novara, Tommaso Prayer Galetti, Tiziano Zambolin, Michael W. Kattan, and G.U.O.N.E. Penile Cancer Project Members Vincenzo FicarraVincenzo Ficarra Department of Urology, University of Verona, Verona , Filiberto ZattoniFiliberto Zattoni Department of Urology, University of Udine, Udine, Italy , Walter ArtibaniWalter Artibani Department of Urology, University of Padua, Padua, Italy , Andrea FandellaAndrea Fandella Department of Urology, Treviso Hospital, Treviso, Italy , Guido MartignoniGuido Martignoni Department of Pathology, Universities of Verona and Sassari, Verona , Giacomo NovaraGiacomo Novara Department of Urology, University of Verona, Verona , Tommaso Prayer GalettiTommaso Prayer Galetti Department of Urology, University of Padua, Padua, Italy , Tiziano ZambolinTiziano Zambolin Department of Urology, University of Brescia, Brescia, Italy , Michael W. KattanMichael W. Kattan Department of Quantitative Health Sciences, The Cleveland Clinic Foundation, Cleveland, Ohio , and G.U.O.N.E. Penile Cancer Project Members View All Author Informationhttps://doi.org/10.1016/S0022-5347(05)01003-7AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: In penile cancer the therapeutic benefits of early inguinal lymphadenectomy must be counterbalanced by the high rates of morbidity, postoperative complications and mortality. A relevant aim is optimizing the selection of the patients who could really have the highest survival advantage from inguinal lymphadenectomy, limiting the cases in which this surgery might be considered over treatment with a risk of severe complications. We generated a nomogram estimating the risk of pathological inguinal lymph node involvement according to clinical lymph node stage and pathological findings of the primary tumor. Materials and Methods: We retrospectively collected the clinical and pathological data of 175 patients who had undergone surgical therapy for squamous cell carcinoma of the penis from 1980 to 2002 at 11 urological centers in northeastern Italy. A logistic regression model was used to construct the nomogram. Results: The presence of palpable groin lymph nodes and the histological findings of vascular and/or lymphatic embolization were important predictors of metastatic inguinal lymph node involvement. The nomogram predicting the risk of metastatic lymph node involvement showed a good concordance index (0.876) and good calibration. Conclusions: The clinical stage of groin lymph nodes and pathological findings of penectomy specimens allowed us to generate a nomogram to predict the probability of metastatic lymph node involvement in patients with squamous cell carcinoma of the penis. 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Google Scholar © 2006 by American Urological AssociationFiguresReferencesRelatedDetailsCited byNazzani S, Catanzaro M, Biasoni D, Maccauro M, Zaborra C, Stagni S, Torelli T, Macchi A, Tesone A, Lorenzoni A, Piva L, Lanocita R, Colecchia M, Montanari E, Salvioni R, Pizzocaro G and Nicolai N (2021) Clinical Outcomes in Clinical N0 Squamous Cell Carcinoma of the Penis According to Nodal Management: Early, Delayed or Selective (following Dynamic Sentinel Node Biopsy) Inguinal Lymph-Node DissectionJournal of Urology, VOL. 206, NO. 2, (354-363), Online publication date: 1-Aug-2021.Gunia S, Erbersdobler A, Hakenberg O, Koch S and May M (2012) p16INK4a is a Marker of Good Prognosis for Primary Invasive Penile Squamous Cell Carcinoma: A Multi-Institutional StudyJournal of Urology, VOL. 187, NO. 3, (899-907), Online publication date: 1-Mar-2012.Sadeghi R, Gholami H, Zakavi S, Kakhki V, Tabasi K and Horenblas S (2011) Accuracy of Sentinel Lymph Node Biopsy for Inguinal Lymph Node Staging of Penile Squamous Cell Carcinoma: Systematic Review and Meta-Analysis of the LiteratureJournal of Urology, VOL. 187, NO. 1, (25-31), Online publication date: 1-Jan-2012.De Paula A, Motta E, Alencar R, Saddi V, da Silva R, Caixeta G, Almeida Netto J and Carneiro M (2011) The Impact of Cyclooxygenase-2 and Vascular Endothelial Growth Factor C Immunoexpression on the Prognosis of Penile CarcinomaJournal of Urology, VOL. 187, NO. 1, (134-140), Online publication date: 1-Jan-2012.Mydlo J (2011) The Quest for Improved Management of Penile CancerJournal of Urology, VOL. 185, NO. 3, (774-776), Online publication date: 1-Mar-2011.Zhu Y, Zhang H, Yao X, Zhang S, Dai B, Shen Y and Ye D (2010) Development and Evaluation of a Nomogram to Predict Inguinal Lymph Node Metastasis in Patients With Penile Cancer and Clinically Negative Lymph NodesJournal of Urology, VOL. 184, NO. 2, (539-545), Online publication date: 1-Aug-2010. Volume 175Issue 5May 2006Page: 1700-1705 Advertisement Copyright & Permissions© 2006 by American Urological AssociationKeywordsnomogramscarcinomasquamous cellneoplasm metastasispenile neoplasmslymph node excisionMetricsAuthor Information Vincenzo Ficarra Department of Urology, University of Verona, Verona Nothing to disclose. More articles by this author Filiberto Zattoni Department of Urology, University of Udine, Udine, Italy Nothing to disclose. More articles by this author Walter Artibani Department of Urology, University of Padua, Padua, Italy Nothing to disclose. More articles by this author Andrea Fandella Department of Urology, Treviso Hospital, Treviso, Italy Nothing to disclose. More articles by this author Guido Martignoni Department of Pathology, Universities of Verona and Sassari, Verona Nothing to disclose. More articles by this author Giacomo Novara Department of Urology, University of Verona, Verona Nothing to disclose. More articles by this author Tommaso Prayer Galetti Department of Urology, University of Padua, Padua, Italy Nothing to disclose. More articles by this author Tiziano Zambolin Department of Urology, University of Brescia, Brescia, Italy Nothing to disclose. More articles by this author Michael W. Kattan Department of Quantitative Health Sciences, The Cleveland Clinic Foundation, Cleveland, Ohio Financial interest and/or other relationship with Oncovance Technologies, Inc. More articles by this author G.U.O.N.E. Penile Cancer Project Members More articles by this author Expand All Advertisement PDF downloadLoading ...