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C-3 Amido-Indole cannabinoid receptor modulators

2002; Elsevier BV; Volume: 12; Issue: 17 Linguagem: Inglês

10.1016/s0960-894x(02)00466-3

1464-3405

John Hynes, Katerina Leftheris, Wu Hong, Chennagiri R. Pandit, Ping Chen, Derek Norris, Bang‐Chi Chen, Rui-Lin Zhao, Peter A. Kiener, Xiaorong Chen, Lori A. Turk, Vina Patil-koota, Kathleen M. Gillooly, David J. Shuster, Kim W. McIntyre,

Neurotransmitter Receptor Influence on Behavior

C-3 Amido-indoles were found to selectively bind to the CB2 receptor. SAR studies led to optimized compounds with excellent in vivo potency against LPS induced TNF-alpha release in murine models of cytokine production.