IntOGen-mutations identifies cancer drivers across tumor types
2013; Nature Portfolio; Volume: 10; Issue: 11 Linguagem: Inglês
10.1038/nmeth.2642
ISSN1548-7105
AutoresAbel González-Pérez, Christian Perez-Llamas, Jordi Deu-Pons, David Tamborero, M. Schroeder, Alba Jené-Sanz, Alberto Santos, Núria López-Bigas,
Tópico(s)Bioinformatics and Genomic Networks
ResumoIntOGen-mutations is a discovery tool for cancer researchers to find driver mutations in genes and pathways. The IntOGen-mutations platform ( http://www.intogen.org/mutations/ ) summarizes somatic mutations, genes and pathways involved in tumorigenesis. It identifies and visualizes cancer drivers, analyzing 4,623 exomes from 13 cancer sites. It provides support to cancer researchers, aids the identification of drivers across tumor cohorts and helps rank mutations for better clinical decision-making.
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