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Effect of Hexamethonium Bromide on the Cerebral Circulation in Hypertension

1953; BMJ; Volume: 2; Issue: 4844 Linguagem: Inglês

10.1136/bmj.2.4844.1017

0959-8138

H. A. Dewar, S. G. Owen, Amy Jenkins,

Optical Imaging and Spectroscopy Techniques

no further trouble.Chemotherapy was continued for over a vear.during which she had a segmental resection of the residual disease.Sumwzmary of Case 3.-A female patient aged 23 developed a high temperature and a morbilliform rash after 22 days on streptomycin and P.A.S. Test doses proved she had become sensitive to both drugs.The daily dose of P.A.S. was gradually increased from 0.5 g. to 15 g. over 11 days; 10 days later it was raised to 17.5 g.Streptomycin doses were increased from 0.1 to 1 g.daily over 12 days.Sub- sequently she continued both drugs for over a year without incident.Summary Desensitization of streptomycin-handlers who have become hypersensitive to the drug is difficult but quite feasible.Two cases are reported.By contrast, patients who acquire hypersensitivity to streptomycin or P.A.S. during treatment are usually readily desensitized.As an example a case is described of a patient hypersensitive to both drugs.My thanks are due to the residents and nursing staff at Hammersmith Hospital, London, the Northern General Hospital, and Southfield Hospital, Edinburgh, who carried out the day-to- day treatment of these patients.