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Beneficial effects of r-h-CLU on disease severity in different animal models of peripheral neuropathies

2007; Elsevier BV; Volume: 190; Issue: 1-2 Linguagem: Inglês

10.1016/j.jneuroim.2007.07.014

1872-8421

Gabriele Dati, Angelo Quattrini, Lilia Bernasconi, Mariachiara Malaguti, Bruno Antonsson, Ferdinando Nicoletti, Chantal Alliod, Roberto Di Marco, Yves Sagot, P.A. Vitte, A. Hiver, Béatrice Gréco, Arthur Roach, Paola Zaratin,

Nuclear Structure and Function

Clusterin is a protein involved in multiple biological events, including neuronal cytoprotection, membrane recycling and regulation of complement-mediated membrane attack after injury. We investigated the effect of recombinant human clusterin in preclinical models of peripheral neuropathies. Daily treatment with clusterin accelerated the recovery of nerve motor evoked potential parameters after sciatic nerve injury. Prophylactic or therapeutic treatment of experimental autoimmune neuritis rats with clusterin also accelerated the rate of recovery from the disease, associated with remyelination of demyelinated nerve fibers. These data demonstrate that clusterin is capable of ameliorating clinical, neurophysiological and pathological signs in models of peripheral neuropathies.