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Prostate Stem Cell Antigen Expression is Associated With Gleason Score, Seminal Vesicle Invasion and Capsular Invasion in Prostate Cancer

2004; Lippincott Williams & Wilkins; Volume: 171; Issue: 3 Linguagem: Inglês

10.1097/01.ju.0000109982.60619.93

1527-3792

Ken‐ryu Han, David B. Seligson, Xueli Liu, Steve Horvath, Peter Shintaku, George Thomas, Jonathan W. Said, Robert E. Reiter,

Prostate Cancer Diagnosis and Treatment

No AccessJournal of UrologyCLINICAL UROLOGY: Original Articles1 Mar 2004Prostate Stem Cell Antigen Expression is Associated With Gleason Score, Seminal Vesicle Invasion and Capsular Invasion in Prostate Cancer KEN-RYU HAN, DAVID B. SELIGSON, XUELI LIU, STEVE HORVATH, PETER I. SHINTAKU, GEORGE V. THOMAS, JONATHAN W. SAID, and ROBERT E. REITER KEN-RYU HANKEN-RYU HAN , DAVID B. SELIGSONDAVID B. SELIGSON , XUELI LIUXUELI LIU , STEVE HORVATHSTEVE HORVATH , PETER I. SHINTAKUPETER I. SHINTAKU , GEORGE V. THOMASGEORGE V. THOMAS , JONATHAN W. SAIDJONATHAN W. SAID , and ROBERT E. REITERROBERT E. REITER View All Author Informationhttps://doi.org/10.1097/01.ju.0000109982.60619.93AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: Few successful therapeutic options exist for men who present with metastatic prostate cancer (CaP) or for the 30% with recurrence. The development and characterization of molecular markers are vital to the development of prognostic and therapeutic modalities in CaP. We investigated the expression and potential clinical usefulness of prostate stem cell antigen (PSCA) in CaP using tissue microarrays. Materials and Methods: Immunohistochemical analysis using a PSCA monoclonal antibody was performed on tissue microarrays constructed from paraffin embedded specimens from 246 patients who underwent radical retropubic prostatectomy. PSCA staining was correlated with established prognostic factors, such as Gleason score, prostate specific antigen (PSA), and seminal vesicle invasion. In addition, recurrence-free survival was analyzed. Results: A high PSCA intensity of 3 was associated with adverse prognostic features, such as Gleason score 7 and above (p = 0.001), seminal vesicle invasion (p = 0.005) and capsular involvement (p = 0.033). On univariate analysis tumors with a PSCA intensity of 3 carried an increased risk of PSA recurrence (p = 0.031, HR 1.77, 95% CI 1.05 to 2.96). However, after adjusting for these variables a PSCA intensity of 3 was no longer an independent predictor of PSA recurrence. Conclusions: We found that high PSCA intensity is significantly associated with adverse prognostic features such as high Gleason score and extra-organ disease. The results of this study suggest that PSCA is a promising tumor marker for the selection of patients at high risk but additional studies are necessary to assess the usefulness of PSCA in patient biopsies. References 1 : Cancer statistics, 2003. CA Cancer J Clin2003; 53: 5. Google Scholar 2 : Prostate stem cell antigen: a cell surface marker overexpressed in prostate cancer. Proc Natl Acad Sci USA1998; 95: 1735. Google Scholar 3 : Anti-PSCA mAbs inhibit tumor growth and metastasis formation and prolong the survival of mice bearing human prostate cancer xenografts. 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Google Scholar From the Departments of Urology (K-RH, RER), Pathology and Laboratory Medicine (DBS, PIS, GVT, JWS), Human Genetics and Biostatistics (XL, SH), University of California-Los Angeles David Geffen School of Medicine, Los Angeles, California© 2004 by American Urological Association, Inc.FiguresReferencesRelatedDetails Volume 171Issue 3March 2004Page: 1117-1121 Advertisement Copyright & Permissions© 2004 by American Urological Association, Inc.Keywordstumor markers, biologicalmiceprostate stem cell antigenprostatic neoplasmsprostateMetricsAuthor Information KEN-RYU HAN More articles by this author DAVID B. SELIGSON More articles by this author XUELI LIU More articles by this author STEVE HORVATH More articles by this author PETER I. SHINTAKU More articles by this author GEORGE V. THOMAS More articles by this author JONATHAN W. SAID More articles by this author ROBERT E. REITER Correspondence: Department of Urology, University of California, CHS 66-128, 10833 Le Conte Ave., Los Angeles, California 90095-1738 (telephone: 310-794-7224; FAX: 310-206-5343). More articles by this author Expand All Advertisement PDF DownloadLoading ...