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A serotonin hypothesis of panic disorder

1988; Wiley; Volume: 3; Issue: 4 Linguagem: Inglês

10.1002/hup.470030409

1099-1077

René S. Kahn, H. M. van Praag,

Neuroendocrine regulation and behavior

Abstract Despite numerous animal studies indicating an important role of serotonin (5‐HT) in anxiety, 5‐HT's function in the regulation of human anxiety has hardly been studied. Recent clinical studies suggest an involvement of 5‐HT systems in panic disorder. This paper will briefly review the pertinent data on 5‐HT and panic disorder and propose a specific hypothesis on 5‐HT abnormalities in that disorder.