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Caenorhabditis elegans RSD-2 and RSD-6 promote germ cell immortality by maintaining small interfering RNA populations

2014; National Academy of Sciences; Volume: 111; Issue: 41 Linguagem: Inglês

10.1073/pnas.1406131111

1091-6490

Aisa Sakaguchi, Peter Sarkies, Matt Simon, Anna-Lisa Doebley, Leonard D. Goldstein, Ashley Hedges, Kohta Ikegami, Stacy M. Alvares, Liwei Yang, Jeannine R. LaRocque, Julie Hall, Eric A. Miska, Shawn Ahmed,

Chromosomal and Genetic Variations

Significance Here, we establish a role for small RNAs in promoting transgenerational fertility via an endogenous temperature-sensitive silencing process that is promoted by the RNAi spreading defective (RSD)-2 and RSD-6 proteins, which have been implicated in RNA interference in response to exogenous double-stranded RNA triggers. This process could be broadly relevant to transgenerational maintenance of heterochromatin and is plausibly relevant to regulation of aging of somatic cells as they proliferate.