Rat gastric somatostatin and gastrin release: Interactions of exendin-4 and truncated glucagon-like peptide-1 (GLP-1) amide
1994; Elsevier BV; Volume: 55; Issue: 8 Linguagem: Inglês
10.1016/0024-3205(94)00489-7
ISSN1879-0631
AutoresR. Eissele, E. Bothe-Sandfort, Burkhard Göke, John Eng, R. Arnold, H. Koop,
Tópico(s)Neuroendocrine Tumor Research Advances
ResumoThe effect of exendin-4, a peptide of the secretin-glucagon family with high homology of amino acid sequence with glucagon-like peptide-1 (GLP-1), on gastric hormone release was investigated in the isolated perfused rat stomach. Exendin-4 dose dependently stimulated somatostatin release up to 9-fold at a concentration of 10−7 M whereas gastrin release was inversely inhibited by up to 63%. These effects could partially be reduced by concomitant perfusion of truncated exendin-4, exendin(9–39)amide. Similarly, stimulation of somatostatin secretion and inhibition of gastrin release induced by GLP-1(7–36)amide was partially reversed by exendin-4 (9–39)amide. These data are consistent with the assumption that exendin-4 and truncated GLP-1amide exert their effects on gastric D and G cell by interaction with the same receptor.
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