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Microwave-assisted solvent-free lipase catalyzed transesterification of β-ketoesters

2012; Taylor & Francis; Volume: 5; Issue: 4 Linguagem: Inglês

10.1080/17518253.2012.672596

1751-8253

Mariela Risso, Mauro Mazzini, Santiago Kröger, Patricia Saenz‐Méndez, Gustavo Seoane, Daniela Gamenara,

Multicomponent Synthesis of Heterocycles

Abstract Lipase-catalyzed transesterification was used as an efficient tool for the interconversion of β-ketoesters. Catalytic activity of commercial lipase B from Candida antarctica (Novozym 435) was evaluated in systems involving non activated acyl donors, and enhanced using microwave irradiation. Interestingly, the combination of CAL B in microwave irradiation worked excellent in solvent-free conditions, thus assuring a highly competitive and environment-friendly process with high yields (up to 96%) in competitive times (< 2h). The combination of biocatalysis with solvent-free systems and microwave assistance is currently scarcely used, and may represent a powerful synergy for preparative reactions.