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Prostate cancer and body size at different ages: an Italian multicentre case–control study

2004; Springer Nature; Volume: 90; Issue: 11 Linguagem: Inglês

10.1038/sj.bjc.6601859

1532-1827

Luigino Dal Maso, Antonella Zucchetto, Carlo La Vecchia, Marco Montella, E. Conti, Vincenzo Canzonieri, Renato Talamini, Alessandra Tavani, Eva Negri, A. Garbeglio, Silvia Franceschi,

Prostate Cancer Treatment and Research

We investigated the influence of anthropometric measures at diagnosis and at different ages on prostate cancer risk using an Italian multicentre case–control study conducted between 1991 and 2002 of 1294 histologically confirmed cases and 1451 controls admitted to the same network of hospitals for acute non-neoplastic conditions. Height, weight, body mass index (BMI), waist-to-hip ratio, lean body mass 1 year before diagnosis/interview were not significantly associated with risk. However, a positive association with high BMI at age 30 years was found (odds ratio=1.2 for BMI⩾24.7 vs <22.7) and: for less differentiated prostate cancer, with BMI 1 year before diagnosis/interview. This study supports possible relationships between high body mass in young adulthood, and a tendency to high weight throughout adult life, and the risk of prostate cancer.