Application of analytical and preparative high-speed counter-current chromatography for separation of alkaloids from Coptis chinensis Franch
1998; Elsevier BV; Volume: 829; Issue: 1-2 Linguagem: Inglês
10.1016/s0021-9673(98)00776-6
ISSN1873-3778
AutoresFuquan Yang, Tianyou Zhang, Ren Zhang, Yoichiro Ito,
Tópico(s)Phytochemical Studies and Bioactivities
ResumoAnalytical high-speed counter-current chromatography (HSCCC) was used for the systematic selection and optimization of the two-phase solvent system to separate alkaloids from Coptis chinensis Franch. The optimum solvent system thus obtained led to the successful separation of alkaloids from C. chinensis Franch by preparative HSCCC. One batch separation yielded four pure alkaloids, including palmatine, berberine, epiberberine and coptisine from the crude alkaloid extract.
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