Raised Numbers of IgG4-Positive Plasma Cells Are a Common Histopathological Finding in Orbital Xanthogranulomatous Disease
2013; Taylor & Francis; Volume: 33; Issue: 1 Linguagem: Inglês
10.3109/01676830.2013.842252
ISSN1744-5108
AutoresRobert M. Verdijk, Pegah Heidari, Roel Verschooten, Paul Van Daele, Huib Simonsz, Dion Paridaens,
Tópico(s)Histiocytic Disorders and Treatments
ResumoPurpose: To determine the relation of orbital xanthogranuloma with IgG4-related disease.Methods: Retrospective consecutive case series over a period of 25 years. We searched our charts for histologically confirmed orbital xanthogranuloma. Patient files were reviewed for clinical and follow up data including presence or absence of systemic non-ophthalmic manifestations of IgG4 related disease. Slides were re-examined and histopathological classification was re-assessed. Sixteen cases of orbital xanthogranuloma were evaluated. Immunohistochemical stains for IgG and IgG4 were performed. Positive immunohistochemical staining required increased IgG4-positive plasma cells in the involved tissues scored as >50 per high-power field, with IgG4/IgG ratio >0.40.Results: According to the criteria described above 8/16 (50%) cases showed increased numbers of IgG4-positive plasma cells in the specimens. Two of these patients may have had signs of systemic diseaseConclusion: Raised numbers of IgG4-positive plasma cells are a common finding in histopathological specimens of xanthogranulomatous disease of the orbit and are often not indicative for IgG4 related systemic disease.
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