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Hyperthermia-induced DNA repair deficiency suggests novel therapeutic anti-cancer strategies

2012; Taylor & Francis; Volume: 28; Issue: 6 Linguagem: Inglês

10.3109/02656736.2012.695427

1464-5157

Berina Eppink, Przemek M. Krawczyk, Jan Stap, Roland Kanaar,

Polyomavirus and related diseases

Local hyperthermia is an effective treatment modality to augment radio- and chemotherapy-based anti-cancer treatments. Although the effect of hyperthermia is pleotropic, recent experiments revealed that homologous recombination, a pathway of DNA repair, is directly inhibited by hyperthermia. The hyperthermia-induced DNA repair deficiency is enhanced by inhibitors of the cellular heat-shock response. Taken together, these results provide the rationale for the development of novel anti-cancer therapies that combine hyperthermia-induced homologous recombination deficiency with the systemic administration of drugs that specifically affect the viability of homologous recombination deficient cells and/or inhibit the heat-shock response, to locally sensitise cancer cells to DNA damaging agents.