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Synthesis and Screening of Potential Antimalarial Agent α-(2-Piperidyl)-2-(1-Adamantyl)-6,8-Dichloro-4-Quinolinemethanol Hydrochloride

1974; Elsevier BV; Volume: 63; Issue: 8 Linguagem: Inglês

10.1002/jps.2600630821

1520-6017

Jaroslav Novotný, Carol H. Collins, Fred W. Starks,

Pharmacogenetics and Drug Metabolism

The synthesis and biological testing of α-(2-piperidyl)-2-(1-adamantyl)-6,8-dichloro-4-quinolinemethanol hydrochloride and its O-acetyl and N-acetyl derivatives are reported. Direct hydrogenation of the α-pyridyl ketone gave very low yields. A novel procedure was developed which permits formation of piperidyl quinolinemethanols in satisfactory yields.