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Diabetic retinopathy is associated with decreased serum levels of free IGF-I and changes of IGF-binding proteins

2000; Elsevier BV; Volume: 10; Issue: 1 Linguagem: Inglês

10.1054/ghir.2000.0140

1532-2238

Berit Feldmann, Peter Jehle, Subburaman Mohan, Gabriele E. Lang, Gerhard Lang, Joachim Brueckel, Bernhard O. Boehm,

Lipid metabolism and disorders

In patients with diabetic retinopathy, elevated serum levels of total circulating insulin-like growth factor-I (IGF-I) have been implicated as an important mediator of the disease. There is no study, however, measuring free IGF-I levels in patients with diabetic retinopathy which mediate the biological effects of IGF-I and are modulated by a complex system of six specific IGF binding proteins (IGFBPs) and several IGFBP proteases.