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Thrombopoietin: In vitro predictions, in vivo realities

1996; Wiley; Volume: 53; Issue: 3 Linguagem: Inglês

10.1002/(sici)1096-8652(199611)53

1096-8652

Kenneth Kaushansky,

Blood properties and coagulation

American Journal of HematologyVolume 53, Issue 3 p. 188-191 Concise ReviewFree Access Thrombopoietin: In vitro predictions, in vivo realities Kenneth Kaushansky, Kenneth Kaushansky Division of Hematology, University of Washington, Seattle, WashingtonSearch for more papers by this author Kenneth Kaushansky, Kenneth Kaushansky Division of Hematology, University of Washington, Seattle, WashingtonSearch for more papers by this author First published: November 1996 https://doi.org/10.1002/(SICI)1096-8652(199611)53:3 3.0.CO;2-VCitations: 4AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat References 1 De Sauvage FJ, Hass PE, Spencer SD, Malloy BE, Gurney AL, Spencer SA, Darbonne WC, Henzel WJ, Wong SC, Kuang W-J, Oles KJ, Hultgren B, Solberg LA Jr, Goeddel DV, Eaton DL: Stimulation of megakaryocytopoiesis, and thrombopoiesis by the c-MpI ligand. Nature 369: 533, 1994. 2 Lok S, Kaushansky K, Holly RD, Kuijper JL, Loften-Day CE, Oort PJ, Grant FJ, Helpel MD, Burkhead SK, Kramer JM, Bell LA, Sprecher CA, Blumberg H, Johnson R, Prunkard D, Ching AFT, Mathewes SL, Balley MC, Forstrom JW, Buddle MM, Osborn SG, Evans SJ, Sheppard PO, Presnell SR, O'Hara PJ, Hagen FS, Roth GJ, Foster DC: Cloning, and expression of murine thrombopoietin cDNA, and stimulation of platelet production in vivo. Nature 369: 565, 1994. 3 Bartley TD, Bogenberger J, Hunt P, Li Y-S, Lu H-S, Martin F, Chang M-S, Samal B, Nichol JL, Swift S, Johnson MJ, Hsu R-Y, Parker VP, Suggs S, Skrine JD, Merewether LA, Clogston C, Hsu E, Hokom MM, Hornkohl A, Choi E, Pangelinan M, Sun Y, Mar V, McNinch J, Simonet L, Jacobsen F, Xie C, Shutter J, Chute H, Basu R, Selander L, Trollinger D, Sieu L, Padilla D, Trail G, Elliott G, Izumi R, Covey T, Crouse J, Garcia A, Xu W, Del Castillo J, Biron J, Cole S, Hu MC-T, Pacifici R, Ponting I, Saris C, Wen D, Yung YP, Lin H, Bosselman RA: Identification, and cloning of a megakaryocyte growth, and development factor that is a ligand for the cytokine receptor. MpI. Cell 77: 1117, 1994. 4 Sohma Y, Akahori H, Seki N, Hori T, Ogami K, Kato T, Shimada Y, Kawamura K, Miyazaki H: Molecular cloning, and chromosomal localization of the human thrombopoietin gene. FEBS Lett 353: 57, 1994. 5 Kuter DJ, Beeler DL, Rosenberg RD: The purification of megapoietin: A physiological regulator of megakaryocyte growth, and platelet production. Proc Natl Acad Sci USA 91: 11104, 1994. 6 Kaushansky K: Thrombopoietin: The primary regulator of platelet production. Blood 86: 419, 1995. 7 McDonald TP: Thrombopoietin: Its biology, purification, and characterization. Exp Hematol 16: 201, 1988. 8 Hill RJ, Levin J: Regulators of thrombopoiesis: Their biochemistry, and physiology. Blood Cells 15: 141, 1989. 9 Kaushansky K, Lok S, Holly RD, Broudy VC, Lin N, Bailey MC, Forstrom JW, Buddle MM, Ort PJ, Hagen FS, Roth GJ, Papayannopoulou T, Foster DC: Promotion of megakaryocyte progenitor expansion, and differentiation by the c-MpI ligand thrombopoietin. Nature 369: 568, 1994. 10 Wendling F, Maraskovsky E, Debili N, Florindo C, Teepe M, Titeux M, Methia N, Breton-Gorius J, Cosman D, Vainchenker W: c-MpI ligand is a humoral regulator of megakaryocytopoiesis. Nature 369: 571, 1994. 11 Zeigler FC, de Sauvage F, Widmer HR, Keller GA, Donahue C, Schreiber RD, Malloy B, Hass P, Eaton D, Matthews W: In vitro megakaryocytopoietic, and thrombopoietic activity of c-mpl ligand (TPO) on purified murine hematopoietic stem cells. Blood 84: 4045, 1994. 12 Choi ES, Nichol JL, Hokom MM, Hornkohl AC, Hunt P: Platelets generated in vitro from proplatelet-displaying human megakaryoeytes are functional. Blood 85: 402, 1995. 13 Tavassoli M, Aoki M: Localization of megakaryocytes in the bone marrow. Blood Cells 15: 3, 1989. 14 Debili N, Wendling F, Katz A, Guichard J, Breton-Gorius J, Hunt P, Vainchenker W: The mpl ligand or thrombopoietin or megakaryocyte growth, and differentiative factor has both direct proliferative, and differentiative activities on human megakaryocyte progenitors. Blood 86: 2516, 1995. 15 Kaushansky K, Broudy VC, Lin N, Jorgensen M, McCarty J, Fox N, Zucker-Franklin D, Lofton-Day C: Thrombopoietin, the MpI-ligand, is essential for full megakaryocyte development. Proc Natl Acad Sci USA 92: 3234, 1995. 16 Broudy VC, Lin NL, Kaushansky K: Thrombopoietin (c-mpl ligand) acts synergistically with erythropoietin, stem cell factor, and IL-11 to enhance murine megakaryocyte colony growth, and increases megakaryocyte ploidy in vitro. Blood 85: 1719, 1995. 17 Farese AM, Hunt, P, Boone T, McVittae TJ: Recombinant human megakaryocyte growth, and development factor stimulates thrombocytosis in normal nonhuman primates. Blood 86: 54, 1995. 18 Basser R, Clarke K, Fox R, Green M, Cebo J, Marty J, Menchaca D, Tomita D, Begley G: Randomized, double-blind, placebo-controlled phase I study of pegylated megakaryocyte growth, and development factor (PEG-rHuMGDF) administered to patients with advanced cancer before, and after chemotherapy. Blood [Suppl] 86: 257, 1995. 19 Chen J, Herceg-Harjacek L, Groopman JE, Grabarek J: Regulation of platelet activation in vitro by the c-MpI ligand, thrombopoietin. Blood 86: 4054, 1995. 20 Harker LA, Hunt P, Marzec UM, Kelly AB, Tomer A, Hanson SR, Stead RB: Dose response effects of pegylated human megakaryocyte growth, and development factor (PEG-rHuMGDF) on platelet production, and function in nonhuman primates. Blood [Suppl] 86: 256, 1995. 21 Zucker-Franklin D, Kaushansky K: The effect of thrombopoietin on the development of megakaryocytes, and platelets: An ultrastructural analysis. Blood 88: 1632, 1996. 22 Gurney AL, Carver-Moore K, de Sauvage FJ, Moore MW: Thrombocytopenia in c-mpl-deficient mice. Science 265: 1445, 1994. 23 De Sauvage FJ, Luoh S-M, Carver-Moore K, Ryan A, Dowd M, Eaton DL, Moore MW: Deficiencies in early, and late stages of megakaryocytopoiesis in TPO-KO mice. Blood 84: 255, 1995. 24 McDonald TP, Sullivan PS: Megakaryocytic, and erythrocytic cell lines share a common precursor cell. Exp Hematol 21: 1316, 1993. 25 Tronik-Le-Roux D, Roullot V, Schweitzer A, Berthier R, Marguerie G: Suppression of erythro-megakaryocytopoiesis, and the induction of reversible thrombocytopenia in mice transgenic for the thymidine kinase gene targeted by the platelet glycoprotein alpha lib promoter. J Exp Med 181: 2141, 1995. 26 Wendling F, Varlet P, Charon M, Tambourin P: A retrovirus complex inducing an acute myeloproliferative leukemia disorder in mice. Virology 149: 242, 1986. 27 Vigon I, Mornon J-P, Cocault L, Mitjavila M-T, Tambourin P, Gisselbrecht S, Souyri M: Molecular cloning, and characterization of MPL, the human homolog of the v-mpl oncogene: Identification of a member of the hematopoietic growth factor receptor superfamily. Proc Natl Acad Sci USA 89: 5640:, 1992. 28 Kaushansky K, Broudy VC, Grossmann A, Humes J, Lin N, Ren H-P, Bailey MC, Papayannopoulou T, Forstrom JW, Sprugel KH: Thrombopoietin expands erythroid progenitors, increases red cell production, and enhances erythroid recovery after myelosuppressive therapy. J Clin Invest 96: 1683, 1995. 29 Kobayashi M, Laver JH, Kato T, Miyazaki H, Ogawa M: Recombinant human thrombopoietin (MgI ligand) enhances proliferation of erythroid progenitors. Blood 86: 2494, 1995. 30 Ku H, Yonemura Y, Kaushansky K, Ogawa M: Thrombopoietin, the ligand for the MpI receptor, synergises with steel factor, and other earlyacting cytokines in supporting proliferation of primitive hematopoietic progenitors of mice. Blood 87: 4544, 1996. 31 Sitnicka E, Lin N, Priestley GV, Fox N, Broudy VC, Wolf NS, Kaushansky K: The effect of thrombopoietin on the proliferation, and differentiation of murine hematopoietic stem cells. Blood 87: 4998, 1996. Citing Literature Volume53, Issue3November 1996Pages 188-191 ReferencesRelatedInformation