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Liposome Encapsulated Doxorubicin Transfer to the Pelvic Lymph Nodes by Endoscopic Administration into the Bladder Wall: A Preliminary Report

1997; Lippincott Williams & Wilkins; Volume: 157; Issue: 5 Linguagem: Inglês

10.1016/s0022-5347(01)64822-5

1527-3792

Takashi Tsuruta, Osamu Muraishi, Yoshihiko Katsuyama, Midori Ichino, Akimi Ogawa,

Urological Disorders and Treatments

No AccessJournal of UrologyClinical Urology: Original Article1 May 1997Liposome Encapsulated Doxorubicin Transfer to the Pelvic Lymph Nodes by Endoscopic Administration into the Bladder Wall: A Preliminary Report Takashi Tsuruta, Osamu Muraishi, Yoshihiko Katsuyama, Murata, Yasushi Midori Ichino, and Akimi Ogawa Takashi TsurutaTakashi Tsuruta More articles by this author , Osamu MuraishiOsamu Muraishi More articles by this author , Yoshihiko KatsuyamaYoshihiko Katsuyama More articles by this author , Midori IchinoMidori Ichino More articles by this author , and Akimi OgawaAkimi Ogawa More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(01)64822-5AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: Liposome encapsulated doxorubicin administered to the pelvic lymph nodes might be effective against pelvic node metastasis. We determined whether the drug can be delivered to the nodes via the bladder wall. Materials and Methods: Ten patients underwent endoscopic administration of 10 mg. liposomal doxorubicin into the bladder wall 3 days before cystectomy. The concentration of doxorubicin in the pelvic lymph nodes obtained at operation was measured. Results: No complication developed after drug administration. Almost all lymph nodes examined contained more than 100 ng./gm. doxorubicin (median 1,860). Conclusions: Endoscopic administration of liposomal doxorubicin into the bladder wall may be an alternative method to deliver doxorubicin to the pelvic lymph nodes. References 1 : Liposomes in the treatment of malignant disease. In: Local Liposome Drug Delivery: An Overlooked Application. Austin: R. G. Landes Co.1992: 59. chapt. 7. Google Scholar 2 : Endoscopic injection of liposomal Adriamycin targeting lymph node metastasis of gastric cancer. Jap. J. Cancer Chemother.1991; 18: 1822. Google Scholar 3 : Study of DDS to the lymph node-metastases of the gastric cancer by the endoscopic injection of lip-ADM. Jap. J. Cancer Chemother.1992; 19: 1591. Google Scholar 4 : Urothelial tumors of the urinary tract. In: . Philadelphia: W. B. Saunders Co.1992: 1094. chapt. 28. Google Scholar 5 : Radical cystectomy for high risk patients with superficial bladder cancer in the era of orthotopic urinary reconstruction. Cancer1995; 76: 833. Crossref, Medline, Google Scholar 6 : Selective bladder preservation by combination treatment of invasive bladder cancer. New Engl. J. Med.1993; 329: 1377. Google Scholar 7 : Characterization of liposomal systems containing doxorubicin entrapped in response to pH gradients. Biochim. Biophys. Acta1990; 1025: 143. Google Scholar 8 : Determination of Adriamycin and its metabolites in biological samples using high performance liquid chromatography, II. Analysis of tissues by extraction method. Yakugaku Zasshi1984; 104: 620. Google Scholar 9 : Adriamycin-a review. J. Nat. Cancer Inst.1975; 55: 1265. Google Scholar 10 : The effect of liposome encapsulated antineoplastic agents on transitional cell carcinoma in tissue culture. J. Urol.1989; 142: 390. Link, Google Scholar From the Departments of Urology and Pharmacy, Shinshu University School of Medicine, Matsumoto, Japan.© 1997 by American Urological Association, Inc.FiguresReferencesRelatedDetailsCited byKIYOKAWA H, IGAWA Y, MURAISHI O, KATSUYAMA Y, IIZUKA K and NISHIZAWA O (2018) DISTRIBUTION OF DOXORUBICIN IN THE BLADDER WALL AND REGIONAL LYMPH NODES AFTER BLADDER SUBMUCOSAL INJECTION OF LIPOSOMAL DOXORUBICIN IN THE DOGJournal of Urology, VOL. 161, NO. 2, (665-667), Online publication date: 1-Feb-1999. Volume 157Issue 5May 1997Page: 1652-1654 Advertisement Copyright & Permissions© 1997 by American Urological Association, Inc.Metrics Author Information Takashi Tsuruta More articles by this author Osamu Muraishi More articles by this author Yoshihiko Katsuyama More articles by this author Midori Ichino More articles by this author Akimi Ogawa More articles by this author Expand All Advertisement PDF downloadLoading ...