Produção Nacional
Revisado por pares
Genome‐wide association study for feedlot average daily gain in Nellore cattle ( Bos indicus )
2014; Wiley; Volume: 131; Issue: 3 Linguagem: Inglês
10.1111/jbg.12084
ISSN1439-0388
AutoresMiguel Henrique de Almeida Santana, Yuri Tani Utsunomiya, Haroldo Henrique de Rezende Neves, Rodrigo da Costa Gomes, José Fernando Garcia, Heidge Fukumasu, Saulo da Luz e Silva, Paulo Roberto Leme, Luiz Lehmann Coutinho, Joanir Pereira Eler, José Bento Sterman Ferraz,
Tópico(s)Cancer-related molecular mechanisms research
ResumoSummary The genome‐wide association study ( GWAS ) results are presented for average daily gain ( ADG ) in Nellore cattle. Phenotype of 720 male Bos indicus animals with information of ADG in feedlots and 354 147 single‐nucleotide polymorphisms ( SNP s) obtained from a database added by information from Illumina Bovine HD (777 962 SNP s) and Illumina Bovine SNP 50 (54 609) by imputation were used. After quality control and imputation, 290 620 SNP s remained in the association analysis, using R package Genome‐wide Rapid Association using Mixed Model and Regression method GRAMMAR ‐Gamma. A genomic region with six significant SNP s, at Bonferroni‐corrected significance, was found on chromosome 3. The most significant SNP (rs42518459, BTA 3: 85849977, p = 9.49 × 10 −8 ) explained 5.62% of the phenotypic variance and had the allele substitution effect of −0.269 kg/day. Important genes such as PDE 4B, LEPR , CYP 2J2 and FGGY are located near this region, which is overlapped by 12 quantitative trait locus ( QTL s) described for several production traits. Other regions with markers with suggestive effects were identified in BTA 6 and BTA 10. This study showed regions with major effects on ADG in Bos indicus in feedlots. This information may be useful to increase the efficiency of selecting this trait and to understand the physiological processes involved in its regulation.
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