Gastric-Mucous Membrane Protection Activity of Coptisine Derivatives.
2001; Pharmaceutical Society of Japan; Volume: 24; Issue: 11 Linguagem: Inglês
10.1248/bpb.24.1277
ISSN1347-5215
AutoresHiroyuki Hirano, Eriko Osawa, Yumiko Yamaoka, Toshio Yokoi,
Tópico(s)Plant-based Medicinal Research
ResumoCoptisine and 8-oxocoptisine were isolated as principles of the gastric-mucous membrane protection from Coptidis rhizoma. The two compounds showed stronger activity than cimetidine and sucralfate. We prepared several derivatives having a partial structure of coptisine from commercially available starting materials. The compounds obtained were tested for gastric-mucous membrane protective activity and a correlation between activity and structure was studied. Our results suggest that the partial charge of the catechol skeleton is related to activity.
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