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Diacylglycerol-mediated insulin resistance

2010; Nature Portfolio; Volume: 16; Issue: 4 Linguagem: Inglês

10.1038/nm0410-400

1546-170X

Derek M. Erion, Gerald I. Shulman,

Diabetes, Cardiovascular Risks, and Lipoproteins

Understanding the molecular mechanisms of insulin resistance remains a major medical challenge of the twenty-first century. Over the last half-century, many hypotheses have been proposed to explain insulin resistance, and, most recently, inflammation associated with alterations in adipocytokines has become the prevailing hypothesis. Here we discuss diacylglycerol-mediated insulin resistance as an alternative and unifying hypothesis to explain the most common forms of insulin resistance associated with obesity and type 2 diabetes mellitus, as well as lipodystrophy and aging.