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Benign Cephalic Histiocytosis: Report of Four Cases

1989; Wiley; Volume: 6; Issue: 3 Linguagem: Inglês

10.1111/j.1525-1470.1989.tb00817.x

1525-1470

Margarita Larralde de Luna, Irene Glikin, Julio Golberg, S Stringa, Roberto Schroh, José Casas,

Parvovirus B19 Infection Studies

We cared for four patients with benign cephalic histiocytosis, a self-healing non-X, nonlipid cutaneous histiocytosis of children. The age of onset of the disease was 5 to 9 months, with papules and erythematous macules involving the head (mainly the cheeks), and posterior spread to the trunk and limbs in three patients. Microscopic examination of skin biopsies revealed a histiocytic infiltrate in the superficial dermis that was S100 protein-negative by immunoperoxidase (PAP method). One patient showed comma-shaped bodies and desmosomelike junctions on electron microscopy. No Birbeck's granules were present. Benign cephalic histiocytosis is a self-limiting condition that requires no treatment.