Portal de Periódicos da CAPES

3,5-Nonadiyne Isolated from the Rhizome of Cachrys ferulacea Inhibits Endogenous Nitric Oxide Release by Rat Peritoneal Macrophages

2004; Pharmaceutical Society of Japan; Volume: 52; Issue: 7 Linguagem: Inglês

10.1248/cpb.52.853

1347-5223

D. Đoković, Vanja M. Bulatović, Biljana Božić Nedeljković, Milena Kataranovski, Tomislav M. Zrakić, Nada Kovačević,

Plant Toxicity and Pharmacological Properties

3,5-Nonadiyne, in vitro, selectively inhibits endogenous nitric oxide release (IC50=6.7±0.8 μM) by rat peritoneal macrophages at doses that do not inhibit T cell proliferation. 3,5-Nonadiyne was isolated from root essential oil of Cachrys ferulacea (L.) CALESTANI, synonym Prangos ferulacea (L.) LINDLEY, obtained by hydrodistillation and spectrometricaly identified unambiguously.