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Aggressive Variant of Morphologically Typical T Large Granular Lymphocyte Leukemia/Lymphoma Lacking NK Cell Markers

2000; Karger Publishers; Volume: 104; Issue: 2-3 Linguagem: Inglês

10.1159/000039762

1421-9662

Roberto Passetto Falcão, Belinda Pinto Simões, Aglair B. Garcia, Benedito Antônio Lopes da Fonseca, João Terra Filho,

CAR-T cell therapy research

A 46-year-old woman with a previous diagnosis of sarcoidosis presented with morphologically typical large granular lymphocyte (LGL) leukemia/lymphoma with an aggressive clinical course. Epstein-Barr virus DNA was detected in peripheral blood mononuclear cells by PCR. The phenotype was typical of the T cell lineage (CD2+ CD3+ CD5+ CD7+ CD8+ TCRalphabeta+) but with the absence of the CD16, CD56, CD57 NK cell markers. In addition, the LGLs expressed CD122 (p75) in the absence of CD25 which is characteristic of LGLs. These leukemic LGLs did not exhibit NK activity. The clonal nature of this proliferation was demonstrated by the rearrangement of the TCRgamma gene. This phenotypically unusual but morphologically typical LGL leukemia/lymphoma may represent the clonal expansion of a minor normal subset of T-LGLs which do not express any NK cell markers, probably corresponding to in vivo activated T cells.