Derivatives of (2R,3R,4S)-2-Aminomethylpyrrolidine-3,4-diol are selective α-Mannosidase inhibitors
2001; Elsevier BV; Volume: 11; Issue: 18 Linguagem: Inglês
10.1016/s0960-894x(01)00477-2
ISSN1464-3405
AutoresFlorence Popowycz, Sandrine Gerber‐Lemaire, Raynald Demange, Eliazar Rodriguez-Garcı́a, Ana T. Carmona, Inmaculada Robina, Pierre Vogel,
Tópico(s)Enzyme Production and Characterization
ResumoA collection of (2R,3R,4S)-3,4-dihydroxypyrrolidin-2-yl derivatives have been tested for their inhibitory activities toward 25 glycosidases. Competitive (Ki=7.4 μM) and selective inhibition of α-mannosidase from jack bean has been found for (2R,3R,4S)-2-[(benzylamino)methyl]pyrrolidine-3,4-diol and other derivatives.
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