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Maternal plasma prostaglandin E 2 metabolite levels during human pregnancy and parturition

1985; Wiley; Volume: 92; Issue: 4 Linguagem: Inglês

10.1111/j.1471-0528.1985.tb01107.x

1471-0528

Shaun P. Brennecke, Bruce Castle, Laurence M. Demers, A. C. Turnbull,

Fatty Acid Research and Health

Summary. Because of methodological problems associated with the measurement in biological fluids of both prostaglandin E 2 (PGE 2 ) and its unstable principal circulating metabolite 13,14‐dihydro‐15‐keto‐PGE 2 (PGEM), there is little reliable information on these prostaglandins in human pregnancy and parturition. The recent discovery of a stable PGEM degradation product 11‐deoxy‐13,14‐dihydro‐15‐keto‐11β, 16‐cyclo‐PGE 2 (bicyclo‐PGEM) has provided a means of studying endogenous plasma levels of PGEM which circumvents the problems encountered with direct measurements of PGE 2 and PGEM. Using a radioimmunoassay for bicyclo‐PGEM we have therefore determined maternal peripheral plasma PGE 2 metabolite levels during human gestation. PGE 2 metabolite levels did not alter significantly during the second or third trimesters nor during labour. This contrasts with maternal peripheral plasma levels of the principal circulating metabolite of PGF 2α 13,14‐dihydro‐15‐keto‐PGF 2α (PGFM) which increases several fold during labour. Compared t o PGE 2 therefore. PGF 2α may be quantitatively the more significant prostaglandin associated with human parturition.