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Sex inclusion in basic research drives discovery

2015; National Academy of Sciences; Volume: 112; Issue: 17 Linguagem: Inglês

10.1073/pnas.1502843112

1091-6490

Sabra L. Klein, Londa Schiebinger, Marcia L. Stefanick, Larry Cahill, Jayne S. Danska, Geert J. De Vries, Melina R. Kibbe, Margaret M. McCarthy, Jeffrey S. Mogil, Teresa K. Woodruff, Irving Zucker,

Sex and Gender in Healthcare

Much of our understanding of disease processes and treatments begins with preclinical studies that use nonhuman animals and cell cultures. Such studies are integral to biomedical research and the development pipeline for drugs, devices, and biologics. Most preclinical biomedical research, however, has been conducted with inadequate consideration of sex (1⇓–3).