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Kerosene Aerosol Induces Guinea-Pig Airway Hyperreactivity to Acetylcholine

1985; Karger Publishers; Volume: 47; Issue: 3 Linguagem: Inglês

10.1159/000194768

1423-0356

Á. Casacó, Ricardo González, Lourdes Arruzazabala, M.A. García, Adolfo Rodríguez de la Vega,

Respiratory and Cough-Related Research

Kerosene aerosol (32.5 mg/l; 20 min), when administered to guinea pigs 1 h before exposure to acetylcholine (Ach), induced potentiation of cumulative dose-response curve of this agonist on isolated tracheal strips as well as a decrease of the lethal doses of Ach. This enhanced response was absent or greatly reduced when kerosene aerosol was administered to guinea pigs 24 h previously or just before Ach challenge. This airway hyperreactivity was also lacking when carbachol or histamine were used as spasmogens instead of Ach. Possible explanations of these results are discussed.