Absence of Genotoxic and Antigenotoxic Effects of a Standardized Extract of the Medicinal Plant Solanum melongena on Peripheral Blood and Bone Marrow Cells of Wistar Rats.
2002; International Society of Cytology; Volume: 67; Issue: 4 Linguagem: Inglês
10.1508/cytologia.67.417
ISSN1348-7019
AutoresDaniele Roswell Chacon, Andreia Nappo Dalla Libera, Dennys Esper Correia Cintra, José Carlos Tavares Carvalho, Gilberto Antônio de Oliveira, Edson Luis Maistro,
Tópico(s)Potato Plant Research
ResumoSince extracts of the fruits of Solanum melongena are rich in flavonoids with a hypolipidemic effect, and because this fruit is widely consumed in Brazil and several others countries, we evaluated the possible genotoxic and cytotoxic activities of a S. melongena extract as well as its possible antigenotoxic effect on peripheral blood reticulocytes and bone marrow cells of Wistar rats. The animals were treated by gavage with 3 concentrations of the extract (25%, 50%, 80% of the LD50 (3 g/kg)) for genotoxic evaluation, and with 50% of the LD50 of the extract+cyclophosphamide for an evaluation of the antigenotoxic potential, for 5 consecutive days. Peripheral blood was collected at 0 h, 48 h, 120 h. The animals were submitted to euthanasia 24 h after the last treatment for chromosome preparations. There was no statistically significant difference in mean micronucleated reticulocytes (MNRETs) or mean number of chromosomal aberrations obtained at the 3 concentrations tested compared with negative control. The same was observed when the antigenotoxic was compared with positive control alone. No significant decrease in mitotic index (MI) was observed for all concentrations of the extract. These findings suggest that the extract of S. melongena, has no genotoxic and cytotoxic effect, and does not protect against cyclophosphamide clastogenicity in Wistar rat cells.
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