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Cancer-selective apoptotic effects of extracellular and intracellular Par-4

2010; Springer Nature; Volume: 29; Issue: 27 Linguagem: Inglês

10.1038/onc.2010.141

1476-5594

Tripti Shrestha-Bhattarai, Vivek M. Rangnekar,

Endoplasmic Reticulum Stress and Disease

Selectivity toward cancer cells is the most desirable element in cancer therapeutics. Par-4 is a cancer cell-selective proapoptotic protein that functions intracellularly in the cytoplasmic and nuclear compartments as a tumor suppressor. Moreover, recent findings indicate that the Par-4 protein is secreted by cells, and extracellular Par-4 induces cancer cell-specific apoptosis by interaction with the cell-surface receptor GRP78. This review describes the mechanisms underlying the apoptotic effects of both extracellular and intracellular Par-4 acting through its effector domain SAC.