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Improved sensitivity of the urine CAA lateral-flow assay for diagnosing active Schistosoma infections by using larger sample volumes

2015; BioMed Central; Volume: 8; Issue: 1 Linguagem: Inglês

10.1186/s13071-015-0857-7

1756-3305

Paul L. A. M. Corstjens, Ruth Nyakundi, Claudia J. de Dood, Thomas Kariuki, Elizabeth A. Ochola, Diana M. S. Karanja, Pauline N. M. Mwinzi, Govert J. van Dam,

Global Maternal and Child Health

Accurate determination of Schistosoma infection rates in low endemic regions to examine progress towards interruption of transmission and elimination requires highly sensitive diagnostic tools. An existing lateral flow (LF) based test demonstrating ongoing infections through detection of worm circulating anodic antigen (CAA), was improved for sensitivity through implementation of a protocol allowing increased sample input. Urine is the preferred sample as collection is non-invasive and sample volume is generally not a restriction.