Cellular Aging: Further Evidence for the Commitment Theory
1981; American Association for the Advancement of Science; Volume: 213; Issue: 4515 Linguagem: Inglês
10.1126/science.7280670
ISSN1095-9203
AutoresR. Holliday, L. I. Huschtscha, Thomas B. L. Kirkwood,
Tópico(s)Genetics, Aging, and Longevity in Model Organisms
ResumoA large, transient reduction in the population size of human fibroblasts in early passages significantly increases the variability of the life-spans of cultures in comparison to control cultures, as predicted by the commitment theory of cellular aging. The theory also predicts that a constant population of noncycling cells will appear in the later part of the culture life-span. This was confirmed by labeling the cells in culture with tritiated thymidine.
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