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Evaluation of LRRK2 G2019S penetrance

2007; Lippincott Williams & Wilkins; Volume: 68; Issue: 14 Linguagem: Inglês

10.1212/01.wnl.0000254483.19854.ef

1526-632X

Stefano Goldwurm, Michele Zini, Luigi Mariani, Silvana Tesei, Rosalba Miceli, Francesca Sironi, Massimo Clementi, Vincenzo Bonifati, Gianni Pezzoli,

Banana Cultivation and Research

We report the results of a family-based study of LRRK2 G2019S penetrance in Parkinson disease. We studied 19 families identified through the analysis of unrelated consecutive patients. The cumulative incidence of the disease was 15% at 60 years, 21% at 70 years, and 32% at 80 years. This study provides accurate estimates of G2019S penetrance by minimizing the selection bias.