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Parathyroid Hormone: Effects of the 3-34 Fragment in Vivo and Vitro

1983; American Association for the Advancement of Science; Volume: 219; Issue: 4580 Linguagem: Inglês

10.1126/science.6849118

1095-9203

John A. McGowan, Tai C. Chen, Jorge Fragola, Jules B. Puschett, Michael Rosenblatt,

Pancreatic function and diabetes

The biologically active fragment of parathyroid hormone, consisting of residues 1-34, and its in vitro antagonist, fragment 3-34, were administered separately or in combination to chronically thyroparathyroidectomized dogs. These fragments were also studied in vitro with dog renal cortical membranes. Fragment 3-34 inhibited the stimulation of adenylate cyclase by fragment 1-34 in vitro, but had no agonist or antagonistic effects on renal phosphate transport in vivo.