Portal de Periódicos da CAPES

INDUSTRIAL SCALE-UP OF COUNTERCURRENT CHROMATOGRAPHY

2001; Taylor & Francis; Volume: 24; Issue: 11-12 Linguagem: Inglês

10.1081/jlc-100104362

1520-572X

Ian Sutherland, A. J. Booth, Les Brown, Bruce E. Kemp, Huw Kidwell, David E. Games, A. S. Graham, G. G. Guillon, David J. Hawes, Michael Hayes, Lee Janaway, Gary J. Lye, Peter R. Massey, Caroline M. Preston, P. Shering, T. Shoulder, C. Strawson, Philip Wood,

Food Quality and Safety Studies

The hydrodynamic, engineering, and chromatographic variables affecting scale-up of countercurrent chromatography (CCC) are examined. The predictable and linear scale-up from the current laboratory scale technology to industrial process scale, capable of kgm/month in the first phase, is demonstrated. Continued research will prepare the way for a new generation of tonne/annum capacity high throughput, high resolution CCC machines for pilot and plant scale separations of a range of bioprocess products.