Produção Nacional
Revisado por pares
Biological studies on Brazilian plants used in wound healing
2009; Elsevier BV; Volume: 122; Issue: 3 Linguagem: Inglês
10.1016/j.jep.2009.01.022
ISSN1872-7573
AutoresC. Schmidt, Márcio Fronza, Márcia Inês Goettert, Fabiana Cristina Geller, Sabine Luik, Érico M.M. Flores, Celso Figueiredo Bittencourt, Gilberto Dolejal Zanetti, Berta Maria Heinzmann, Stefan Laufer, Irmgard Merfort,
Tópico(s)Phytochemistry Medicinal Plant Applications
Resumon-Hexanic and ethanolic extracts from twelve plants (Brugmansia suaveolens Brecht. et Presl., Eupatorium laevigatum Lam., Galinsoga parviflora Cav., Iresine herbstii Hook., Kalanchöe tubiflora Hamet-Ahti, Petiveria alliacea L., Pluchea sagittalis (Lam.) Cabrera, Piper regnellii DC., Schinus molle L., Sedum dendroideum Moç et Sessé ex DC., Waltheria douradinha St. Hill., Xanthium cavanillesii Schouw.) used in traditional South Brazilian medicine as wound healing agents were investigated in various biological assays, targeting different aspects in this complex process. The extracts were investigated on NF-κB DNA binding, p38α MAPK, TNF-α release, direct elastase inhibition and its release as well as on caspase-3. Fibroblasts migration to and proliferation into the wounded monolayers were evaluated in the scratch assay, the agar diffusion test for antibacterial and the MTT assay for cytotoxic effects. The hydrophilic extracts from Galinsoga parviflora, Petiveria alliacea, Schinus molle, Waltheria douradinha and Xanthium cavanillesii as well as the lipophilic extract of Waltheria douradinha turned out to be the most active ones. These results increase our knowledge on the wound healing effects of the investigated medicinal plants. Further studies are necessary to find out the effective secondary metabolites responsible for the observed effects.
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