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BIBTEX RIS

Immunization with SARS Coronavirus Vaccines Leads to Pulmonary Immunopathology on Challenge with the SARS Virus

2012; Public Library of Science; Volume: 7; Issue: 4 Linguagem: Inglês

10.1371/journal.pone.0035421

ISSN

1932-6203

Autores

Chien‐Te K. Tseng, Elena Sbrana, Naoko Iwata‐Yoshikawa, Patrick C. Newman, Tania Garron, Robert L. Atmar, C. J. Peters, Robert B. Couch,

Tópico(s)

Animal Virus Infections Studies

Resumo

Severe acute respiratory syndrome (SARS) emerged in China in 2002 and spread to other countries before brought under control. Because of a concern for reemergence or a deliberate release of the SARS coronavirus, vaccine development was initiated. Evaluations of an inactivated whole virus vaccine in ferrets and nonhuman primates and a virus-like-particle vaccine in mice induced protection against infection but challenged animals exhibited an immunopathologic-type lung disease.

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