Portal de Periódicos da CAPES

Whole-body ring-shaped confocal photoacoustic computed tomography of small animals in vivo

2012; SPIE; Volume: 17; Issue: 5 Linguagem: Inglês

10.1117/1.jbo.17.5.050506

1560-2281

Jun Xia, Muhammad Rameez Chatni, Konstantin Maslov, Zijian Guo, Kun Wang, Mark A. Anastasio, Lihong V. Wang,

Ultrasound and Hyperthermia Applications

We report a novel small-animal whole-body imaging system called ring-shaped confocal photoacoustic computed tomography (RC-PACT). RC-PACT is based on a confocal design of free-space ring-shaped light illumination and 512-element full-ring ultrasonic array signal detection. The free-space light illumination maximizes the light delivery efficiency, and the full-ring signal detection ensures a full two-dimensional view aperture for accurate image reconstruction. Using cylindrically focused array elements, RC-PACT can image a thin cross section with 0.10 to 0.25 mm in-plane resolutions and 1.6 s/frame acquisition time. By translating the mouse along the elevational direction, RC-PACT provides a series of cross-sectional images of the brain, liver, kidneys, and bladder.