Artigo Acesso aberto Revisado por pares

Tunable Nanostructured Coating for the Capture and Selective Release of Viable Circulating Tumor Cells

2015; Volume: 27; Issue: 9 Linguagem: Inglês

10.1002/adma.201404677

ISSN

1521-4095

Autores

Eduardo Reátegui, Nicola Aceto, Eugene J. Lim, James P. Sullivan, Anne Eeg Jensen, Mahnaz Zeinali, Joseph M. Martel, Alexander J. Aranyosi, Wei Li, Steven Castleberry, Aditya Bardia, Lecia V. Sequist, Daniel A. Haber, Shyamala Maheswaran, Paula T. Hammond, Mehmet Toner, Shannon L. Stott,

Tópico(s)

Microfluidic and Bio-sensing Technologies

Resumo

A layer-by-layer gelatin nanocoating is presented for use as a tunable, dual response biomaterial for the capture and release of circulating tumor cells (CTCs) from cancer patient blood. The entire nanocoating can be dissolved from the surface of microfluidic devices through biologically compatible temperature shifts. Alternatively, individual CTCs can be released through locally applied mechanical stress.

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