Tunable Nanostructured Coating for the Capture and Selective Release of Viable Circulating Tumor Cells
2015; Volume: 27; Issue: 9 Linguagem: Inglês
10.1002/adma.201404677
ISSN1521-4095
AutoresEduardo Reátegui, Nicola Aceto, Eugene J. Lim, James P. Sullivan, Anne Eeg Jensen, Mahnaz Zeinali, Joseph M. Martel, Alexander J. Aranyosi, Wei Li, Steven Castleberry, Aditya Bardia, Lecia V. Sequist, Daniel A. Haber, Shyamala Maheswaran, Paula T. Hammond, Mehmet Toner, Shannon L. Stott,
Tópico(s)Microfluidic and Bio-sensing Technologies
ResumoA layer-by-layer gelatin nanocoating is presented for use as a tunable, dual response biomaterial for the capture and release of circulating tumor cells (CTCs) from cancer patient blood. The entire nanocoating can be dissolved from the surface of microfluidic devices through biologically compatible temperature shifts. Alternatively, individual CTCs can be released through locally applied mechanical stress.
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