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The nuclear envelope: form and reformation

2005; Elsevier BV; Volume: 18; Issue: 1 Linguagem: Inglês

10.1016/j.ceb.2005.12.004

1879-0410

Amy Prunuske, Katharine S. Ullman,

RNA regulation and disease

The membrane system that encloses genomic DNA is referred to as the nuclear envelope. However, with emerging roles in signaling and gene expression, these membranes clearly serve as more than just a physical barrier separating the nucleus and cytoplasm. Recent progress in our understanding of nuclear envelope architecture and composition has also revealed an intriguing connection between constituents of the nuclear envelope and human disease, providing further impetus to decipher this cellular structure and the dramatic remodeling process it undergoes with each cell division.