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BIBTEX RIS

Hepatitis C Virus Infection: Molecular Pathways to Insulin resistance

2011; BioMed Central; Volume: 8; Issue: 1 Linguagem: Inglês

10.1186/1743-422x-8-474

ISSN

1743-422X

Autores

Fahed Parvaiz, Sobia Manzoor, Huma Tariq, Farakh Javed, Kaneez Fatima, Ishtiaq Qadri,

Tópico(s)

Alcohol Consumption and Health Effects

Resumo

Abstract Chronic Hepatitis C virus has the potential of inducing insulin resistance and type 2 Diabetes Mellitus in vitro as well as in vivo . Structural and non-structural proteins of HCV modulate cellular gene expression in such a way that insulin signaling is hampered, concomitantly leads toward diabetes mellitus. A number of mechanisms have been proposed in regard to the HCV induced insulin resistance involving the upregulation of Inflammatory cytokine TNF-α, hypophosphorylation of IRS-1 and IRS-2, phosphorylation of Akt, up-regulation of gluconeogenic genes, accumulation of lipids and targeting lipid storage organelles. This review provides an insight of molecular mechanisms by which HCV structural and non-structural proteins can induce insulin resistance.

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